Projects of the Pasteur Institute International Network
– Development of a low-cost diagnostic platform for SARS-CoV-2 based on reverse transcription loop-mediated isothermal amplification (RT-LAMP), a rapid response solution for high demand of laboratory diagnostics during virus outbreaks in PINA (obtained).
– Epidemiological, clinical, and immunological analyzes of SARS-CoV-2 cases in the metropolitan area of São Paulo, Brazil: a descriptive study (obtained).
– Immunological biomarkers and their correlation with the progression and severity of Covid-19: a prospective study of a cohort from São Paulo and Cayenne (submitted).
São Paulo Research Foundation (FAPESP)
Diagnosis of SARS-CoV-2 infection, phylogenetic investigation, and analysis of the pathophysiology of Covid-19 (FAPESP thematic addendum, submitted).
National Council for Scientific and Technological Development (CNPq)
– Investigation of the host-parasite relationship of SARS-CoV-2 isolates circulating in the metropolitan region of São Paulo: immune response, phylogenetic analysis, and viral dynamics (submitted).
– Immunopathogenesis of Covid-19 in Experimental Models. Focus on clinical questions (submitted).
RUDIC Platform – Coronavirus Integrated Diagnostic Network and associated projects
– Epidemiological, clinical, and immunological analysis of SARS-CoV-2 cases in the metropolitan region of São Paulo: A descriptive study.
– Direct comparison of the sensitivity and specificity of different molecular diagnostic assays for SARS-CoV-2 available on the WHO website.
– Diagnostic support for the medical teams of Hospital das Clínicas and the University Hospital of the University of São Paulo by the Laboratory for urgent response to biological threats of the Center for Advanced Studies and Epidemic Control of SARS-CoV-2 of the Pasteur-USP Scientific Platform, São Paulo-SP, Brazil.
– Phylogenetic analysis of SARS-CoV-2 in different phases of the viral epidemic and in patients with various degrees of symptom severity (asymptomatic, mild symptoms, severe symptoms, critical symptoms and deceased), treated in different hospitals in the capital of São Paulo, including Hospital das Clinics and the University Hospital.
– Analysis of viral presence and kinetics in different clinical samples obtained from asymptomatic and symptomatic individuals infected with SARS-CoV-2.
– Analysis of the importance of asymptomatic individuals in the maintenance and transmission of SARS-CoV-2 on the University of São Paulo campus, São Paulo-SP, Brazil (CRUSP, PM, SAS, USP security force)
– Analysis of different cell culture systems for isolation, cultivation, and SARS-CoV-2 plating.